54Centuries: 1st century BC - 1st century - 2nd century
- October 13 - Roman Empire emperor Claudius dies after being poisoned by Agrippina, his wife and niece.
- Nero succeeds Claudius as emperor of Roman Empire
- Patriarch Onesimus succeeds Stachys the Apostle as Patriarch of Constantinople.
- Judea is returned piecemeal to Agrippa I's son Marcus Julius Agrippa between 48 and 54.
- Paul of Tarsus begins his third mission.
- Apollos, a later assistant of Paul, is converted to Christianity in Ephesus