1516Centuries: 15th century - 16th century - 17th century
- March - With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I.
- July - Selim I of the Ottoman Empire declares war on the Mameluks and invades Syria.
- August 13 - Treaty of Noyon - Peace between France and Spain. Francis recognizes Charles's claim to Naples, and Charles recognizes Francis's claim to Milan.
- August 24 - Battle of Merj-Dabik. The Ottomans defeat the Mameluks, who abandon Syria.
- October 28 - Battle of Yaunis Khan. Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza.
- December 4 - Treaty of Brussels - Peace between France and the Empire.