1496Centuries: 14th century - 15th century - 16th century
- January 3 - Leonardo da Vinci unsuccessfully tests a flying machine
- March 10 - Christopher Columbus leaves Hispaniola for Spain, ending his second visit to the Western Hemisphere.
- July - Spanish forces under Gonzalo Hernandez de Cordoba capture Atella after a siege. Among the prisoners is the French viceroy of Naples, the Comte de Montpensier. Ferrante II is restored to the throne of Naples.
- Jesus College (University of Cambridge) founded.